The research situation in the field of tinnitus research is extremely poor. An article in the Medical Tribune Germany dated 30.11.2019 rightly complains that too little research is being conducted in the field of tinnitus, and patients feel abandoned by medicine.

A particularly bad opinion is given there to cognitive behavioral therapy which is promoted by most health insurances. In the hope that the sound disappears, this therapy only teaches how to cope in everyday life or how to suppress the sound. This is of course not meeting the needs of the patients but is cheap. Over the years, the tinnitus sound becomes louder for most patients, and thus this suppression strategy reaches its expiration date, and the patient finds themselves at the beginning of the next odyssey.

Currently, only the Tailor-Made Notched Music Training (TMNMT) in combination with heat therapy can provide relief or healing. The first clinical observational study on tinniwell was conducted by Dr. Ebbers in Düren from October 2016 to July 2017, with 30 patients participating. In this study, a complete recovery was documented in one patient after just 4 weeks; on average, all patients experienced a relief of 54% already after 4 weeks. A double-blind study on tinniwell will start this fall with 60 patients.

Through the monitoring of Resaphene in 250 patients from January 2019 – February 2020, 4 phases of therapy have now been identified. In Phase 1, the tinnitus gets louder during or immediately after treatment. This can occur after just 2 days but can also take up to 5 weeks. This is then the indication that the therapy is effective for the patient. In Phase 2, the tinnitus sound decreases and becomes quieter. Phase 3 is a big surprise for patients, as the tinnitus partially disappears during the day. In the final Phase 4, it also disappears at night. It is then advisable to continue the therapy for another 3 weeks at the last known frequency, as the tinnitus will remain permanently gone. A premature termination causes the tinnitus to reappear in its old form within a week. Overall, reaching Phase 4 has been observed after 3-4 months with a daily therapy duration of two hours.

In the past, two studies on Tailor-Made Notched Music Training were conducted at the University of Münster. In the second study, participants were advised to discontinue therapy in case of a worsening of tinnitus. According to our findings, this was the reason for the poor results from this study. An improvement in tinnitus for the patient is always preceded by a worsening.

++ About Resaphene Suisse AG

Resaphene Suisse AG, based in Roggwil, Switzerland, is a medical technology company founded in 2015, which has been selling a tinnitus therapy device under the name tinniwell since 2016. Other distribution companies include Resaphene Deutschland GmbH in Constance, Resaphene UK Ltd. in London, and Resaphene US LLC

in the USA.

++ Contact for inquiries:

Resaphene Suisse AG

Bahnhofplatz 5

9322 Egnach

Switzerland

Contact:

Ms. Anke Rauterkus (Chief Executive Officer)

a.rauterkus@resaphene.ch